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Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs (Drugs and the Pharmaceutical Sciences) J. Hauss David
Publisher: Informa Healthcare

There is a great interest and medical need for the improvement of bioavailability of a large number of herbal drugs and plant extracts which are poorly lipid soluble and so less bioavailable1. In human Assistant Professor, CT Institute of Pharmaceutical Sciences, Jallandhar- But their phytosomal formulations show improved absorption, enhanced delivery and increased bioavailability of phytochemicals than the conventional herbal extracts containing dosage forms. INTRODUCTION Recently synthesized drug which can be being discovered are lipophillic in nature and have poor aqueous solubility, thereby posing problems within their formulation into delivery systems. Nanoparticles offer a unique platform for the formulation of poorly soluble drugs – such formulations can be injected (intravenous, subcutaneous, intramuscular), as well as administered through other routes, such as oral, ocular and inhalation. This causes problems when creating a dosage form, as lack of solubility in water leads to poor bioavailability, variation in therapeutic effect from one patient to the next (or even from one dose to the next in the same patient) and variable dose proportionality. Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs. For a water-insoluble drug, the absorption and bioavailability could be restricted by dissolution rate and solubility in the GI tract. The particle size reduction techniques enhance the dissolution rate of the poorly water soluble drugs due to the enormous surface area that is generated. INTRODUCTION Recently synthesized drug which are being discovered are lipophillic anyway and have poor aqueous solubility, thereby posing problems in their formulation into delivery systems. For their low of insoluble drugs. Because of their low The Self-Dispersing Lipid Formulations (SDLFs) is among the promising approaches to overcome the formulation difficulties of various hydrophobic/lipophillic drugs also to improve the oral bioavailability of poorly absorbed drugs. Improves wettability with simultaneous increase in porosity of granules resulting enhanced surface area producing higher dissolution rate and bioavailability of poorly water-soluble drug. The low solubility of poorly water-soluble drugs and surfactants in supercritical CO2 and the high pressure required for these processes restrict the utility of this technology in the pharmaceutical industry22. The Self-Dispersing Lipid Formulations (SDLFs) is among the promising approaches to beat the formulation difficulties of various hydrophobic/lipophillic drugs and to improve the oral bioavailability of poorly absorbed drugs. Enhancing solubility and bioavailability, optimizing formulation, and improved delivery methods all play key roles in maximizing a drug's potential, improving patient compliance and ultimately patient health. A pharmaceutical scientist's approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound's physiochemical properties, solid-state modifications, advanced . Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs (Drugs and the Pharmaceutical Sciences) Oral Lipid-Based.